Busulfan feature : ABCDEF
Alkylating agent
Bone marrow suppression
CML Indication
Dark skin(hyperpigmentation)
Endocrine insufficiency(adrenal)
Fibrosis
Drugs causing Torsades de Pointes:APACHE
Amiodarone
Procainamide
Arsenium
Cisapride
Haloperidol
Erythromycin
Morphine side effects :MORPHINE
Myosis
Out of it(sedation)
Respiratory depression
Pneumonia(aspiration)
Hypotension
Infrequency(constipation,urina
ry retention)
Nausea
Emesis
Aspirin side effects :ASPIRIN
Asthma
Salicylism
Peptic ulcer disease/phosphorylation-oxidat
ion uncoupling/platelet disaggregation
Intestinal blood loss
Reye’s Syndrome
Idiosyncracy
Noise(tinnitus)
SSRIs side effects :SSRI
Seratonin syndrome
Stimulate CNS
Reproductive disfunction in male
Insomnia
Inhalation anesthetics : SHINE
Sevoflane
Halothane
Isoflurane
Nitrous oxide
Enflurane
Teratogenic drugs :”Win TERATogenic
Warfarin
Thalidomide
Epileptic drugs:Phenytoin,Valproate,Carb
amazepine
Retinoid
ACE inhibitor
Third element :Lithium
Gynaecomastia causing drugs:DISCOS
Digoxin
Isoniazid
Spironolactone
Cimetidine
Oestrogens
Stilboestrol
Methyldopa Side effects :METHYLDOPA
Mental retardation
Electrolyte imbalance
Tolerance
Headache/ Hepatotoxicity
psYcological upset
Lactation in female
Dry mouth
Oedema
Parkinsonism
Antirheumatic agents :CHAMP
Cyclophosphamide
Hydroxycloroquine and choloroquinine
Auranofin and other gold compounds
Methotrexate
Penicillamine
Phenytoin: adverse effects PHENYTOIN
P-450 interactions
Hirsutism
Enlarged gums
Nystagmus
Yellow-browning of skin
Teratogenicity
Osteomalacia
Interference with B12 metabolism (hence anemia)
Neuropathies: vertigo, ataxia, and headache
Sodium Valproate side effccts VALPROATE
Vomiting
Alopecia
Liver toxicity
Pancreatitis/ Pancytopenia
Retention of fats (weight gain)
Oedema (peripheral oedema)
Appetite increase
Tremor
Enzyme inducer (liver)
Amiodarone: action, side effects: 6 P’s:
Prolongs action potential duration
Photosensitivity
Pigmentation of skin
Peripheral neuropathy
Pulmonary alveolitis and fibrosis
Peripheral conversion of T4 to T3 is inhibited -> hypothyroidism

Antiparkinson Drugs :SALAD
Selegiline
Anticholinenergics (trihexyphenidyl, benzhexol, ophenadrine)
L-Dopa + peripheral decarboxylase inhibitor (carbidopa, benserazide)
Amantadine
Dopamine postsynaptic receptor agonists (bromocriptine, lisuride, pergolide)
Therapeutic Index Formula TILE
TI = LD / ED
Anti epeleptic drugs Dr.BHAISAB’s New PC.
Deoxy barbiturates
Barbiturates
Hydantoin
Aliphatic carb acids
Iminostilbenes
Succinimides
BZD’s
Newer drugs
Phenyltriazines
Cyclic gaba analogues
Adverse effects of Tetracyclines-KAPIL DEV
Kidney toxicity
Antianabolic effect
Phototoxicity
Liver toxicity
Diabetes insipidus
CAPTOPRIL Side effects CAPTOPRIL
Cough Angioedema
Agranulocystosis
Proteinuria/ Potassium excess
Taste changes
Orthostatic hypotension
Pregnancy contraindication/ Pancreatitis/ Pressure drop (first dose hypertension)
Renal failure (and renal artery stenosis contraindication)/ Rash
Indomethacin inhibition
Leukopenia/Liver toxicity
Lithium: side effects LITH
Leukocytosis
Insipidus [diabetes insipidus, tied to polyuria]
Tremor/ Teratogenesis
Hypothyroidism
Myocardial Infarction(MI): signs and symptoms PULSE
Persistent chest pains
Upset stomach
Lightheadedness
Shortness of breath
Excessive sweating
MI: basic management (Shortcut:BOOMAR)
Bed rest
Oxygen
Opiate
Monitor
Anticoagulate
Reduce clot size
Treatment of Heart Failure: ABCDE
ACE inhibitors
Beta-blockers
Calcium channel blockers
Diuretics
Endothelin-converting enzyme inhibitors
Essential Amino acids
Methionine
Threonine
Leucine
Isoleucine
Tryptophan
Valine
Lysine
Phenyl alanine

——————