Q1. Which class of drug closely relates to:
“Hepatotoxicity and jaundice, urinary retention and azoospermia, prostatic hypertrophy and priapism and paradox-ical gynecomastia.”
(a)
Antithyroid agents

(b) Sulfonylurea oral hypoglyccemics

(c) Adrenocorticosteroids

(d)  Androgens

 

Q2. Which of the following antihypertensives act on the vasomotor centre:

(a) prazosin

(b) methyldopa

(c) hydralazine

(d) reserpine

 

Q3. Haloperidol:

(a) is particularly prone to producing hypotensive side-effects

(b) is particularly prone to producing extrapyramidal side-effects

(c) is particularly prone to producing arrhythmias

(d) is particularly prone to producing anti-muscarinic side-effects

 

Q4. Angiotensin increases peripheral resistance by

(a) Direct vasoconstriction

(b) Catecholamine release from adrenal medulla

(c) Noradrenaline release from sympathetic nerve terminals

(d) All of the above

 

Q5. Effects of beta blockers include:

(a) stimulation of aqueous humour production

(b)inhibition of bronchial smooth muscle spasm

(c) stimulation of lipolysis via the sympathetic nervous system

(d) inhibition of glycogenolysis in the liver

 

Q6. Regarding phenytoin, all the following are true EXCEPT:

(a) oral bioavailability is variable

(b)binds poorly with plasma proteins

(c) metabolism is enhanced in presence of inducers of liver metabolism

(d) elimination kinetics shift from first order to zero order at moderate to high dose

 

Q7. Regarding inhaled anaesthetics:

(a) nitrous oxide has a relatively low minimum alveolar concentration

(b) halogenated agents have a lower brain : blood partition coefficient

(c) they reduce mean arterial pressure in direct proportion to their alveolar concentration

(d) nitrous oxide causes a decrease in tidal volume and an increase in respiratory rate

 

Q8. Regarding glucocorticoids:

(a) The major glucocorticoid in humans is cortisol

(b) A normal adult male secretes 100mg of cortisol each day

(c) Feedback suppression of pituitary ACTH occurs within hours

(d) Absence of cortisol increases the response of vascular and smooth muscle tone to catecholamines

 

Q9. The insulin receptor is

(a) Tyrosine protein kinase receptor
(b) G protein coupled receptor
(c) Ion channel regulating receptor
(d) None of these

Q10. Following is a tertiary amine anti-mus-carinic drug mainly used for mydriatic or cycloplegic action
(a) Benztropine

(b) Dicyclomine

(c) Pirenzepine

(d) Trpicamide

 


1-D         2-B       3-B           4-D          5-D      6-B      7-C      8-A          9- A          10-D