Q1. Local anesthetics produce:
a) Analgesia, amnesia, loss of consciousness
b) Blocking pain sensation without loss of consciousness
c) Alleviation of anxiety and pain with an altered level of consciousness
d) A stupor or somnolent state
Q2. A good local anesthetic agent shouldn’t cause:
a) Local irritation and tissue damage
b) Systemic toxicity
c) Fast onset and long duration of action
d) Vasodilatation
Q3. Granulocytopenia, gastrointestinal irritati on, gingival hyperplasia, and facial hirsutism are possible adverse effects of:
a) Phenobarbital
b) Carbamazepin
c) Valproate
d) Phenytoin
Q4. Most local anesthetic agents consist of:
a) Lipophylic group (frequently an aromatic ring)
b) Intermediate chain (commonly including an ester or amide)
c) Amino group
d) All of the above
Q5. Which of the following agents is  the precursor of dopamine?
a) Bromocriptine
b) Levodopa
c) Selegiline
d) Amantadine
Q6. Indicate the nonopioid agent of central effect with analgesic activity:
a) Reserpine
b) Propranolol
c) Clopheline
d) Prazosin
Q7. Which one of the following groups is responsible for the duration of the local anesthetic action?

a) Intermediate chain
b) Lipophylic group
c) Ionizable group
d) All of the above
Q8. Which of the following statements concerning nitrate mechanism of action is True?
a) Therapeutically active agents in this group are capable of releasing nitric oxide (NO) in to vascular smooth muscle target tissues
b) Nitric oxide (NO) is an effective activator of soluble guanylyl cyclase and probably acts mainly through this mechanism
c) Nitrates useful in angina decrease myocardial oxygen requirement (by decreasing the determinations of oxygen demand) and increase myocardial oxygen delivery (by reversing coronary arterial spasm)
d) All of the above
Q9. All of the following statements concerning the general principles  of therapy with lipid-lowering drugs are true EXCEPT:

a) Therapy with a lipid-lowering drug should be always accompanied by an appropriate diet
b) A lipid-lowering diet should be discontinued if it fails to decrease the levels of plasma LDL cholesterol by at least 10%
c) Lipid-lowering drugs should only be administered after at least 3 months of  prior dietary therapy
d) Some combinations of lipid-lowering drugs are synergistic
Q10. All of the following statements concerning vitamin E functions are true, EXCEPT:
a) An extremely important antioxidant, which protects cell membrane lipids from peroxidation by breaking the chain reaction of free radical formation to which polyunsaturated fatty acids are particularly vulnerable
b) Antisterility and antiabortion factor
c) Specifically required for synthesis of prothrombin and several other clotting factors
d) An essential for oxidative processes regulation

1-b;        2-c;    3-d;     4-d;    5-b;    6-c;    7-a;    8-d;    9-b;    10-c

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