1. Indicate a cholinesterase inhibitor, which has an additional direct nicotinic agonist effect:
a) Edrophonium
b) Carbochol
c) Neostigmine
d) Lobeline

2. Which vitamin is useful in alcoholism?
a) Thiamine
b) Pyridoxine
c) Folic acid
d) Ascorbic acid

3. Local anesthetics are:
a) Weak bases
b) Weak acids
c) Salts
d) None of the above

4. Which of the following is not a prodrug?
I)captopril                    II)enalapril             III)ramipril             IV)lisinopril
a) I and II
b) II and III
c) I and IV
d) III and IV

5. Aliskiren acts by
a) Inhibiting the conversion of Angiotensin I to II
b) Inhibiting the release of rennin
c) Inhibiting the binding of Angiotensin II to the receptor
d) Inhibiting the action of aldosterone

6. Drugs following one compartment open model pharmacokinetics eliminate
a) Mono-exponentially
b) Bi-exponentially
c) Tri-exponentially
d) Non-exponentially

7. Which of the following statements is not correct for local anesthetics?
a) In a tissue they exist either as an uncharged base or as a cation
b) A charged cationic form penetrates biologic membranes more readily than an uncharged form
c) Local anesthetics are much less effective in inflamed tissues
d) Low pH in inflamed tissues decreases the dissociation of nonionized molecules.

8. Coulter counter is used in determination of
a) Particle surface area
b) particle size
c) Particle volume
d) All of the above

9. The common structural feature amongst the three categories of anticonvulsant drugs barbiturates, succinimides and hydantoins is
a) ureide
b) imidazolidinone
c) dihydropyrimidine
d) tetrahydropyrimidine

10. Drug and Magic Remedy act is also called as
a) Objectionable Drugs Act
b) Objectionable Treatment Act
c) Objectionable Advertisement Act
d) Magical drugs act

1-c; 2-a; 3-a; 4-c; 5-b; 6-a; 7-b; 8-d ; 9- a; 10-c

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