NIPER-JEE is a common entrance exam to MS/MBA courses at NIPERs across the nation. The exam is conducted annually in the month of June/July. Being the founding institution, the exam was conducted and managed by NIPER, Mohali till 2015 but with the emergence and growth of other NIPERs, the recent NIPER-JEE 2016 was conducted by NIPER Hyderabad.
Though the conducting authority of NIPER-JEE changed last year, the basic pattern of exam and the eligibility conditions stood intact. Being the same, to be eligible to appear in NIPER-JEE, one has to qualify GPAT.

Since the status of NIPERs is grand, the competition is supreme. Last year, 2500 (approximate) GPAT qualified candidates competed for 600 (approximate) NIPER seats. These numbers may not imply as severe competition as actually it is. This is because the competition is among nations’ finest pharmacy graduates who have already proved their contendership in GPAT. It is important to mention that NIPER also gives another opportunity to those who have not been able to perform to the best of their capabilities in GPAT. So the time after GPAT till NIPER is not a “let it go” period, instead its very crucial period for those whose GPAT rank is not very satisfactory. One has to put all his heart and soul to turn the table in NIPER. Don’t under estimate the importance of anything, right from a simple senior’s advice to professional coaching may prove worthy. The most important thing is just keep the flame for mare burning. GPAT is not it, you have to make it large, you have to make it great and you have to make it worth…..you have to make it to the NIPERs.

National Institute of Pharmaceutical Education and Research (NIPER) was established as a centre of excellence for higher training, research and development in pharmaceutical sciences and technology and its first institute of this kind in the country. The first NIPER was set up at Mohali, Punjab. The prestigious institute has been declared as an institute of national importance by Government of India. Subsequently, 6 new NIPERs were setup at Hyderabad, Ahmedabad, Hajipur, Guwahati, Kolkata, and Rae Bareli.





The various departments in this institute are listed below:

1. Medicinal chemistry
2. Natural products
3. Pharmacology and toxicology
4. Pharmaceutics
5. Pharmaceutical analysis
6. Pharmaceutical technology (Process chemistry)
7. Pharmaceutical technology (Formulation)
8. Pharmaceutical technology (Biotechnology)
9. Biotechnology
10. Pharmacy Practice
11. Pharmacoinformatics
12. M. B. A. (Pharm)
13. Clinical Research.
14. Regulatory Toxicology
15. Medical Devices

For general information go to NIPER web site www.niper.gov.in or www.niper.nic.in
The conducting authorities of GPAT and NIPER are different, so is their focus. While GPAT is more of a low scoring accuracy based exam focusing on pharmacy related subjects, NIPER is a speed based high scoring exam that in addition to pharmacy based questions encompasses questions on general aptitude, English, logical reasoning and current affairs. Even the pharmacy related questions differ from GPAT as the questions that appear in NIPER JEE are mainly application based with special focus on basics and concepts. So, cramming doesn’t work in NIPER-JEE. One has to have a sound conceptual foundation and ample practice to clear NIPER.
We have compiled sets of certain points for each subject. These are just grids for the study and are helpful for the specialization papers. You need not to be thorough of it but if not
thoroughly, at least you should be aware of it. None of it should be something heard first. By the way most of these are covered in B. Pharm syllabus.

What to study?

Pharmaceutical Analysis

1. Spectroscopy: Most important topic for NIPER-JEE exam. Things like Sources, detectors etc.

• NMR, and C-NMR ranges from Pavia
• Mass spectroscopy, Basic concepts about various peaks, M+1, molecular ion, base peak etc.(Silverstein)
• IR, Frequencies of various groups specially carbonyls (Pavia)
• UV Woodward – Fischer rules and calculations

2. Chromatography: Detailed study.
3. Basic concept of DSC, DTA, TGA
4. Basic concepts of Acid-base titration, redox titration
5. Concepts of Osmolality, osmolarity, osmotic pressure, conductivity, Electrophoresis, limit test




Organic Chemistry

1. Main reactions like
a) Cannizaro
b) Prin
c) Aldol condensation
d) Perkin
e) Dickman
f) Darzen
g) Beckmann Rearrangement
h) Birch Reduction
i) Claisen Condensation
j) Curtius Rearrangement
k) Diels-Alder Reaction
l) Hell-Volhard-Zelinsky Reaction
m) Hofmann Degradation
n) Hofmann Reaction
o) Hydroboration Reaction
p) Meerwein-Ponndorf-Verley Reduction
q) Pinacol Coupling Reaction
r) Reimer-Tiemann Reaction
s) Schotten-Baumann Reaction
t) Ullmann Reaction
u) Wittig Rearrangement

2. Stereochemistry: Most important topics are listed below:
a) R and S nomenclature
b) Diastereomers, enantiomers
c) E and Z isomerism
d) Atropo isomerism
e) Stereoselectivity
f) Stereospecificity
g) Regioselectivity
h) Chemoselectivity
i) Chirality
j) Conformation rearrangements
k) Racemic mixtures resolution
l) Imine-enamine Tautomerism
m) Keto-enol tautomerism

3. IUPAC Nomenclature, Hybridization: Basic knowledge of this.
4. Fischer, sawhorse and newman projections.
5. Pericylic reaction
6. Mechanism of E1, E2, SN1 and SN2
7. Various rules like- Aromaticity rule, Huckel’s rule, Markonikov rule, Bredt rule, Sytzeff rule etc.
8. Ester hydrolysis
9. Heterocyclic chemistry
10. Oxidizing & reducing agents like sodium borohydride, chromic acid & their use in named reactions
11. Various stability and reactivity orders (Carbocation, Carbanion, Free radicle etc.)

Medicinal Chemistry

1. SAR (ANS, Benzodiazepines and barbiturates are important)
2. Isosterism
3. Prototype moieties of molecules
4. Starting synthesis material
5. Steroids

Biochemistry

1. Knowledge of various basic concepts of biochemistry is very important for NIPER-JEE.
2. Amino acids, Classifications, protein and structure, various methods for amino acid detection, Ninhydrin test, peptide sequencing, structures of amino acids, essential and nonessential amino acids, urea cycle,
3. Carbohydrates, Classification, osazone test, Mutorotation, Various method for carbohydrate detection, glycolysis and citric acid cycle
4. Lipids, Classification, β-Oxidation.
5. Enzymes: Active site, Functional groups, Enzyme-Substrate complex, Co-factors, Michaelis-menten equation, Enzyme inhibition, Isoenzymes, Allosterism
6. Co-enzymes

Natural Products

1. Biosynthetic pathways
2. Method of extraction, isolation and characterization of various phytoconstituents
3. Secondary metabolites, various classes of secondary metabolites (e.g. Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, anthocyanidines etc.).
4. Plant growth regulators (e.g. Auxin, gibberlins, Cytokinin etc)
5. Marine Natural Products
6. Plant tissue culture
7. Analytical Pharmacognosy i.e. type of stomata, Trichomes, ash value, lycopodium spore method.

Pharmacology and toxicology

1. Pharmacokinetics, pharmacodynamics, pharmacological effect, desired, undesired, toxic, adverse effects.
2. Various factors of ADME
3. Drug metabolism: various pathways and other details.
4. Drug interactions, agonist, antagonist, partial agonist, protein binding, drug distribution, distribution volume, excretion pathways etc.
5. Pharmacological screening: general principles, various screening models, screening methodologies (in vitro and in vivo tests).
6. Mechanism of drug action, drug-receptor interaction.
7. Various adrenergic, cholinergic and other receptors
8. Detailed study of CNS pharmacology
9. Study of basis of threshold areas of work in NIPER in pharmacology dept. mentioned in brochure.
10. Diseases: study of the pharmacology of the diseases and drugs used with mode of action especially of diabetes, malaria, leishmaniasis, TB, hypertension, myocardial ischemia, inflammation, and immunomodualtion.
11. Chemotherapy and pathophysiology- knowledge of antibiotics, their mode of action and the microorganisms responsible for various common diseases.
12. Bioassay methods, various requirements. Brief knowledge of the statistical tests.
13. Basic Mechanism of all drugs with major side effects and classification
14. Receptor classification with example
15. Drug development, clinical trials, Pathophysiology of CNS diseases, NOAEL, LOAEL concepts, Toxicity guideline, OECD guidelines, Safety guidelines.

Biotechnology and Microbiology

1. DNA replication, Transcription and Translation
2. Recombinant DNA technology including Bacterial transformation, transduction, etc. PCR, Southern, Northern blotting, Plasmid-Vector concept, restriction endonuclease enzymes etc.
3. Immunology: Antigen- Antibody concepts, types of antibodies, concepts of Innate/ Adaptive/ immunity, epitope, Hypersensitivity reactions, ELISA, Immunofluorescence tests etc.
4. Microorganism Staining
5. Tables of Microbiology like antibiotic assay, serological tests, antibiotic source etc.




Physical Pharmacy and Pharmaceutical dosage forms

1. Solid state pharmaceutics: Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity, surface area, flow properties.
2. Pre-formulation
3. Various concepts of acid-base, pH, pKa, Surfactants, HLB scale, Cyclodextrins, Inclusion compounds
4. Stability testing, shelf life determination, thermal stability, accelerated stability testing
5. Tablets, capsules, emulsion, suspension, Parenteral products, Aerosols, Microencapsulation (Only size ranges), Suppositories (Only bases), Semisolid (Only bases).
6. Packaging (specifically types of containers)
7. Novel Drug Delivery System: NDDS models, osmotic pumps, various release patterns e.g. Controlled release, delayed release. Sustained release etc. order of release. Oral controlled DDS, factors affecting controlled release. polymers and their classification, types.
8. Drug targeting: microspheres, nano-particles, liposomes, monoclonal antibodies, etc.
9. Transdermal drug delivery systems (TDDS): principles, absorption enhancers, evaluation of TDDS.
10. Rheology, Surface tension, complexation, reaction kinetics, first, second, third and pseudo first order reactions, radio labelling for determination of mechanism.

Pharmacokinetics and Biopharmaceutics

Basic concepts of compartment modelling, bioavailability, Bioequivalence, IVIVC.

Miscellaneous:
1. Various forms mentioned in Pharmaceutical jurisprudence and various member in state pharmacy council and PCI.
2. Only basic concepts of below points
a) QSAR
b) Proteomics
c) Genomics
d) Latest Approved US-FDA approved and banned drugs
e) Current affairs (Specially related to Pharmacy field):
f) General Awareness:
a) Current major sports tournaments
b) Heads of various sports organisations (Like in NIPER 2011 it was asked “who is the chairman of BCCI”).
c) Brand product of various pharmaceutical companies
d) Which Endorsements done by which personality
g) Some Aptitude related question: We don’t have to go in details for aptitude related questions.
h) Ramachandran Plot
i) English language and Comprehension: Synonyms and Antonyms

NIPER’s Thrust areas are

a) Microbial and viral diseases: Yeast, and fungi.
b) Parasitic and tropical diseases: Malaria, Leishmaniasis, amoebiasis, cancer, aids etc.
c) Metabolic Disorders: Diabetes Strokes
d) Oxidizing, reducing agents & Stereochemistry
e) Organic reactions & mechanisms
f) Peptide and carbohydrate chemistry.
g) Genomics and proteomics: yeast and fungi
h) Hormonal disorders: Sex & TSH related diseases.

Exam Pattern

Unlike GPAT, NIPER is an OFFLINE Exam. The exam consists of 200 questions based on Complete B. Pharm syllabus and some general English vocabulary, Logical reasoning, Pharmacy Current affairs. The duration of exam is 2 hours.

NIPER v/s GPAT

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